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lumacaftor/ivacaftor will reduce the level or effect of abemaciclib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Keep away from or Use Alternate Drug. Coadministration of abemaciclib with potent CYP3A4 inducers lessens plasma concentration of abemaciclib and its metabolites.Your Health care provider will prescribe a steroid-made up of